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What is depression and can one avoid depression? Depression is a negative outlook of a person towards themselves, their environment, and their future. There are multiple indicators of the same that range from crying spells, low mood, disturbed sleep, and much more. These signs observed over two weeks are categorized as depression. One can always train themselves to overcome a reactive depression that arises as a person’s reaction to a situation. However, clinical depression is something that cannot be avoided as it is embedded in one’s genes. That being said, significant changes can be seen in people with clinical depression with the help of medication on counseling.